abstract：:Thiobarbituric acid reactive substances (TBARS) in 38 low density lipoprotein (LDL) samples from 21 healthy male non-smokers and 17 smokers (greater than 20 cigarettes per day) were measured before and after oxidation. TBARS in the freshly isolated LDL from non-smokers and smokers were similar, however, oxidized LDL s...

journal_title：Atherosclerosis

authors： Scheffler E,Huber L,Frühbis J,Schulz I,Ziegler R,Dresel HA

更新日期：1990-06-01 00:00:00

abstract：:The relationships between plasma lecithin:cholesterol acyltransferase (LCAT) mass concentrations and lipids, apolipoprotein, and lipoprotein subfraction concentrations were studied in men assigned at random to a one-year exercise program (n = 48) and to a sedentary control condition (n = 31). Exercise training did not...

journal_title：Atherosclerosis

authors： Williams PT,Albers JJ,Krauss RM,Wood PD

更新日期：1990-05-01 00:00:00

abstract：:Forty patients with NIDDM and hyperlipoproteinemia were selected for a 12-week double-blind placebo-controlled trial to study the effects of metformin on lipoprotein concentration and composition. A significant decrease occurred in VLDL-apo B and all lipid components of VLDL, indicating a decreased number of circulati...

journal_title：Atherosclerosis

authors： Schneider J,Erren T,Zöfel P,Kaffarnik H

更新日期：1990-05-01 00:00:00

abstract：:Blood serum of most patients with coronary heart disease (CHD) caused a 2-5-fold increase in the total cholesterol content of smooth muscle cells cultured from unaffected human aortic intima, i.e. possessed an atherogenic potential manifested in culture. Removal of immunoglobulins G and M from an atherogenic serum bro...

journal_title：Atherosclerosis

authors： Tertov VV,Orekhov AN,Sayadyan KS,Serebrennikov SG,Kacharava AG,Lyakishev AA,Smirnov VN

更新日期：1990-04-01 00:00:00

abstract：:Accelerated coronary atherosclerosis is a major risk limiting long-term survival after heart transplantation and is commonly associated with dyslipoproteinemia even in subjects who were not dyslipoproteinemic before intervention. The purpose of this study was to analyse the abnormalities in the lipid profiles of 2 dif...

journal_title：Atherosclerosis

authors： Atger V,Cambillau M,Guillemain R,Farge D,Dreyfus G,Hamon S,Girard A,Carpentier A,Moatti N

更新日期：1990-03-01 00:00:00

abstract：:The hypolipidaemic effect of guar gum (30 g/day) was examined in a double blind placebo-controlled crossover study in 9 patients with primary hyperlipidaemia. The treatment periods were of six weeks duration. Cholesterol levels in low density lipoprotein (LDL) were decreased by 11.5% and in intermediate density lipopr...

journal_title：Atherosclerosis

authors： Turner PR,Tuomilehto J,Happonen P,La Ville AE,Shaikh M,Lewis B

更新日期：1990-03-01 00:00:00

abstract：:We investigated the modulating effect of serum total triglycerides on the lipid composition of various lipoproteins, and on the response to gemfibrozil treatment. This placebo controlled study was conducted blind in 60 participants of the Helsinki Heart Study. An inverse relationship was observed between cholesterol c...

journal_title：Atherosclerosis

authors： Mänttäri M,Koskinen P,Manninen V,Huttunen JK,Frick MH,Nikkilä EA

更新日期：1990-02-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) has been proposed as a potential tool in the evaluation of atherosclerotic lesions. However, two basic difficulties have to date prevented the full exploitation of the potentials of this technique: the poor spatial resolution of the conventional tomographs and the wide variety of the l...

journal_title：Atherosclerosis

authors： Asdente M,Pavesi L,Oreste PL,Colombo A,Kuhn W,Tremoli E

更新日期：1990-01-01 00:00:00

abstract：:Serum lipids, lipoprotein (a), plasminogen activator inhibitor and tissue plasminogen activator levels were measured in 260 subjects, constituting a cross-section sample of 30-60-year-old men and women. For Lp(a), there were positive correlations with age and cholesterol, but not with any of other measured parameters....

journal_title：Atherosclerosis

authors： Sundell IB,Nilsson TK,Hallmans G,Hellsten G,Dahlén GH

更新日期：1989-11-01 00:00:00

abstract：:The ultrastructure of the aortic intima and serum lipid levels in Fischer 344 rats were examined at the ages of 12, 18 and 24 months after feeding the animals an atherogenic diet (2% cholesterol, 0.25% sodium cholate, 5% beef fat) for 6 months. Structural changes in the intima were noticeable only at the age of 24 mon...

journal_title：Atherosclerosis

authors： Nakamura H,Izumiyama N,Nakamura K,Ohtsubo K

更新日期：1989-10-01 00:00:00

abstract：:Plasma high density lipoproteins (HDL) and their major protein, apolipoprotein (apo) A-I, are deficient in homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits. As the pathophysiology of subnormal HDL-apo A-I is unclear, we examined kinetic parameters of HDL-apo A-I in WHHL rabbits and normolipidemic Japanese W...

journal_title：Atherosclerosis

authors： Saku K,Yamamoto K,Sakai T,Yanagida T,Hidaka K,Sasaki J,Arakawa K

更新日期：1989-10-01 00:00:00

abstract：:Rabbit apolipoprotein A-I (apo A-I) of molecular weight 27,612 contained 241 amino acids. In contrast to its human counterpart which has 3 methionine residues, the rabbit protein possesses only one and therefore produces 2 fragments after CNBr cleavage (CNBr I and II, NH2- and COOH-terminal, respectively). From a seri...

journal_title：Atherosclerosis

authors： Leroy A,Vu-Dac N,Theret N,Pio F,Fruchart JC

更新日期：1989-09-01 00:00:00

abstract：:Changes in the concentration and composition of serum very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were studied in rabbits transferred from chow diet to cholesterol-free, semipurified diets containing casein or isolated soy protein. The fat and fibre content of ...

journal_title：Atherosclerosis

authors： Kurowska EM,Hrabek-Smith JM,Carroll KK

更新日期：1989-08-01 00:00:00

abstract：:The purpose of this study was to compare the histologic variability of atheromas resected from patients with various risk factors for vascular disease. Twenty-seven plaques obtained using the Simpson atherectomy catheter were studied. The results of this light and electron microscopic study indicate that patients with...

journal_title：Atherosclerosis

authors： Barbano EF,Newman GE,McCann RL,Hackel DB,Stack RS,Palmos LE,Mikat EM

更新日期：1989-08-01 00:00:00

abstract：:We have investigated the association between serum high density lipoprotein-cholesterol (HDL-C) and apo A-I concentration and the PstI and XmnI restriction fragment length polymorphisms of the apolipoprotein AI-CIII-AIV multigene complex. Two groups of subjects were examined. The first comprised 174 unrelated male pat...

journal_title：Atherosclerosis

authors： Wile DB,Barbir M,Gallagher J,Myant NB,Ritchie CD,Thompson GR,Humphries SE

更新日期：1989-07-01 00:00:00

abstract：:Cholesteryl ester transfer from solid-phase bound HDL to endogenous plasma HDL or VLDL/LDL was determined in 50 patients with primary disorders of lipid metabolism and 27 normolipidemic subjects. Transfer to the plasma HDL pool was significantly reduced in familial hypercholesterolemia, familial combined hyperlipidemi...

journal_title：Atherosclerosis

authors： Sparks DL,Frohlich J,Lacko AG,Pritchard PH

更新日期：1989-06-01 00:00:00

abstract：:Elevated serum cholesterol is a risk factor in the development of coronary artery disease. Magnesium has been reported to decrease total serum cholesterol, low density lipoprotein, and very low density lipoprotein, and increase high density lipoprotein. A randomized, double-blind, placebo-controlled, crossover study w...

journal_title：Atherosclerosis

authors： Marken PA,Weart CW,Carson DS,Gums JG,Lopes-Virella MF

更新日期：1989-05-01 00:00:00

abstract：:The relationship of fetal plasma cholesterol levels to aortic free and esterified cholesterol concentration was determined in the rabbit during gestation. Plasma cholesterol levels (mg/dl) in early fetuses were markedly high and decreased at term. While aortic free cholesterol content increased with fetal age, cholest...

journal_title：Atherosclerosis

authors： Cayatte AJ,Subbiah MT

更新日期：1989-04-01 00:00:00

abstract：:Various oils have been used as vehicles for cholesterol in diets used to produce atherosclerosis in rabbits. Because such oils may affect the physico-chemical properties of the beta-VLDL produced in response to cholesterol feeding, we have studied the physico-chemical characteristics of beta-VLDL isolated from cholest...

journal_title：Atherosclerosis

authors： Waugh DA,Tercyak AM,Small DM

更新日期：1989-04-01 00:00:00

abstract：:Rabbits were fed cholesterol for 14 weeks to study the effect of probucol on atheroma formation. Three groups of animals were investigated: group CHOL was fed 1% cholesterol and served as control for group P + CHOL. fed 1% cholesterol and 1% probucol from the onset till the end of the experiment: group CHOL + P receiv...

journal_title：Atherosclerosis

authors： Stein Y,Stein O,Delplanque B,Fesmire JD,Lee DM,Alaupovic P

更新日期：1989-02-01 00:00:00

abstract：:Tendon xanthoma are a hallmark of familial hypercholesterolemia and are among its earliest clinical manifestations. Achilles tendon size, advanced to a generally accepted marker, is virtually specific for the disease and easily accessible for measurement. Hypercholesterolemic patients with coronary heart disease have ...

journal_title：Atherosclerosis

authors： Steinmetz A,Schmitt W,Schuler P,Kleinsorge F,Schneider J,Kaffarnik H

更新日期：1988-12-01 00:00:00

abstract：:The interaction of mouse peritoneal and human pericardial macrophages with lipoprotein (LP)-antibody (Ab) immune complex isolated from the serum of ischemic heart disease (IHD) patients has been studied. It is shown that the Ab of the autoimmune complex belongs to IgG class, and the antigen is the LP with d less than ...

journal_title：Atherosclerosis

authors： Klimov AN,Denisenko AD,Vinogradov AG,Nagornev VA,Pivovarova YI,Sitnikova OD,Pleskov VM

更新日期：1988-11-01 00:00:00

abstract：:The effects of the artificial triglyceride-phospholipid emulsion (10% intralipid) on HDL subfraction were studied in vivo. After a 14-h fast, subjects received intralipid via a 4-h infusion. Serum lipoproteins were analyzed before and at 4 and 6 h after the start of the infusion. At 4-h the following acute changes by ...

journal_title：Atherosclerosis

authors： Sakuma N,Lin C,Matsumoto Y,Ikeuchi R,Ichikawa T,Hirata H,Noguchi Y,Fujinami T

更新日期：1988-11-01 00:00:00

abstract：:We looked for antibodies against endothelial cells, monocytes, fibroblasts, lymphocytes and Epstein-Barr virus transformed lymphocytes in the sera of 28 elderly and 18 middle-aged patients with atherosclerotic peripheral arterial disease and 13 controls. Inclusion criteria were symptomatic peripheral arterial disease ...

journal_title：Atherosclerosis

authors： D'Anastasio C,Impallomeni M,McPherson GA,Clements WG,Howells GL,Brooks PA,Batchelor JR

更新日期：1988-11-01 00:00:00

abstract：:Experiments were performed on thoracic aortae of 12 male Sprague-Dawley [corrected] rats to determine the statistical frequency of isolated leaks to Evans blue-albumin (EBA) conjugate at the level of individual cells and to assess the relationship of such leaks to the cell turnover process. Fluorescence microscopy was...

journal_title：Atherosclerosis

authors： Lin SJ,Jan KM,Schuessler G,Weinbaum S,Chien S

更新日期：1988-10-01 00:00:00

abstract：:In 137 living subjects, arteriosclerotic change in the human abdominal aorta was examined in relation to coronary heart disease (CHD) using a new ultrasonic method. The pressure strain elastic modulus (Ep) was calculated as an index of elastic properties from which arteriosclerotic change in the aorta was estimated. T...

journal_title：Atherosclerosis

authors： Imura T,Yamamoto K,Satoh T,Mikami T,Yasuda H

更新日期：1988-10-01 00:00:00

abstract：:Changes of serum apolipoprotein levels were studied every hour for 6 h after the administration of 55 g butter to 8 healthy male subjects. The mean serum apo A-IV level was significantly increased at 4 h (P less than 0.05) after fat ingestion compared to the mean initial level, although no significant changes of level...

journal_title：Atherosclerosis

authors： Seishima M,Noma A,Torizawa H,Muto Y

更新日期：1988-09-01 00:00:00

abstract：:Porphyrins are known to be accumulated in vivo by tumors and atherosclerotic plaques. We studied the interaction of cultured aortic smooth muscle cells (SMC) from spontaneously atherosclerotic Broad Breasted White Turkeys (BBWT) with free hematoporphyrin (Hp) and low density lipoprotein (LDL)-Hp complexes. A significa...

journal_title：Atherosclerosis

authors： Scannapieco G,Pagnan A,Pauletto P,Mattiello A,Biffanti S,Jori G,Dal Palù C

更新日期：1988-08-01 00:00:00

abstract：:DNA probes for all eight of the major apolipoprotein genes are now available. The chromosomal location, the basic structure and in many cases the nucleotide sequences of the normal genes are known. Common DNA polymorphisms of all of the genes have been detected. These have been been used in a number of ways to investi...

journal_title：Atherosclerosis

authors： Humphries SE

更新日期：1988-08-01 00:00:00

abstract：:A Japanese group comprising 53 hyperlipidemic and 54 normolipidemic subjects was genotyped for DNA restriction fragment length polymorphisms (RFLPs) at the apo B gene locus. The polymorphisms with XbaI and PvuII were present at allelic frequencies of 0.04 (X1 allele) and 0.96 (X2 allele), 0.94 (P1 allele) and 0.06 (P2...

journal_title：Atherosclerosis

authors： Aburatani H,Matsumoto A,Itoh H,Yamada N,Murase T,Takaku F,Itakura H

更新日期：1988-07-01 00:00:00

abstract：:Dietary plant proteins may lower plasma cholesterol and LDL concentrations in hypercholesterolemic patients when substituted for animal proteins, particularly in diets with low cholesterol and saturated fat content. Plant protein diets appear, however, to be without effect on plasma lipoprotein levels in normal subjec...

journal_title：Atherosclerosis

authors： Meinertz H,Faergeman O,Nilausen K,Chapman MJ,Goldstein S,Laplaud PM

更新日期：1988-07-01 00:00:00

abstract：:The role of prostaglandin I2 (PGI2) in the control of DNA synthesis during the cell cycle was investigated in cultured rabbit aortic smooth muscle cells (SMC). SMC at confluency in the G0 state reached the S phase about 16 h after stimulation with serum, as judged by measurement of [3H]thymidine incorporation into DNA...

journal_title：Atherosclerosis

authors： Morisaki N,Kanzaki T,Motoyama N,Saito Y,Yoshida S

更新日期：1988-06-01 00:00:00

abstract：:Rabbits fed a commercial chow diet containing 0.5% cholesterol and 14% coconut oil developed more severe hyperlipidemia and atherosclerosis than rabbits fed the same diet containing olive oil in place of coconut oil. Average plasma cholesterol was twice as high in the coconut oil/cholesterol-fed rabbits than in olive ...

journal_title：Atherosclerosis

authors： Van Heek M,Zilversmit DB

更新日期：1988-06-01 00:00:00

abstract：:In a random sample of 22 normolipidaemic male Caucasian individuals, 35-49 years old, homozygosity for the X2 allele (cutting site) of the XbaI RFLP of the apo B gene was associated with higher mean total cholesterol and LDL-cholesterol concentration. These individuals also had significantly lower LDL fractional catab...

journal_title：Atherosclerosis

authors： Houlston RS,Turner PR,Revill J,Lewis B,Humphries SE

更新日期：1988-05-01 00:00:00

abstract：:Subendothelial cells (SEC) were obtained from the inner intimal layer of adult human aorta by collagenase treatment. SEC were identified in primary culture either as smooth muscle cells by staining with FITC-labeled antisera against human smooth muscle myosin or as macrophages, foam cells and contaminating endothelial...

journal_title：Atherosclerosis

authors： Babaev VR,Antonov AS,Zacharova OS,Romanov YA,Krushinsky AV,Tsibulsky VP,Shirinsky VP,Repin VS,Smirnov VN

更新日期：1988-05-01 00:00:00

abstract：:The effect of endothelial cells (EC) on the binding and internalisation of beta-very low density lipoprotein (beta-VLDL) and the subsequent accumulation of lipid was investigated in cultured smooth muscle cells (SMC) of different phenotype. The following combinations were examined: (i) SMC cultured and incubated with ...

journal_title：Atherosclerosis

authors： Horrigan S,Campbell JH,Campbell GR

更新日期：1988-05-01 00:00:00

abstract：:Prolonged exposure of rats to cigarette smoke resulted in significant alterations in the metabolism of lipids. There was a significant increase in the concentration of cholesterol, triglycerides and phospholipids in most of the tissues, particularly the heart, aorta and lungs. Cholesterol, triglycerides and phospholip...

journal_title：Atherosclerosis

authors： Latha MS,Vijayammal PL,Kurup PA

更新日期：1988-04-01 00:00:00

abstract：:The mechanisms of inflammation responsible for the myocardial tissue damage seen after an acute myocardial infarction (AMI) have not been clearly identified. Recent lines of evidence, demonstrating depressed sera levels of individual complement components in patients after myocardial infarction, have suggested involve...

journal_title：Atherosclerosis

authors： Langlois PF,Gawryl MS

更新日期：1988-03-01 00:00:00

abstract：:Familial dysbetalipoproteinemia is characterized by hyperlipidemia, increases in beta-migrating, very low density lipoproteins (beta-VLDL), and homozygosity for apolipoprotein E2 (apo E2). In this study, 3 patients with familial dysbetalipoproteinemia were treated with lovastatin, and kinetics for apolipoprotein B (ap...

journal_title：Atherosclerosis

authors： Vega GL,East C,Grundy SM

更新日期：1988-03-01 00:00:00

abstract：:Although it has been widely acknowledged that endothelial injury is an important contributing factor to the pathogenesis of atherosclerosis, and may even represent an initiating event, morphologic documentation of its occurrence both in humans and animals has been difficult to obtain. However, electrical stimulation o...

journal_title：Atherosclerosis

authors： Gutstein WH

更新日期：1988-03-01 00:00:00